The following is a list of drugs with which ciprofloxacin should not be used simultaneously:
- Tizanidine (a muscle relaxant used to treat muscle stiffness or spasticity). Ciprofloxacin affects the metabolism of tizanidine and its simultaneous use causes very low blood pressure and severe somnolence.
- Corticosteroids (for example, traviselolone, hydrocortisone, methylprednisolone and others). Co-administration with corticosteroids increases the risk of tendinitis.
- Hydrocodone (narcotic analgesic). Ciprofloxacin increases the level of hydrocodone in the blood, which may lead to side effects.
- Theophylline (medicine that used to treat asthma). Ciprofloxacin increases the concentration of theophylline in the blood, which can cause a potentially fatal arrhythmias.
- Buproprion (an antidepressant). Attendant use increases a seizures risk.
- Antiarrhythmics (droperidol and ibutilide). Attendant use increases the risk of arrhythmia.
- Warfarin. Attendant use increases the risk of bleeding.
- Mifepristone (a medicine used to stop pregnancy). Attendant use increases the risk of arrhythmia.
- Pentoxifylline (a drug used to treat peripheral circulatory disorders).
Ciprofloxacin can cause the following side effects:
- Skin rash, itching or hives
- Fungal superinfections
- Increased numbers of eosinophils in the blood
- Digestive disorders
- CNS symptoms (headache, drowsiness, confusion, hallucinations, depression, anxiety, etc.)
- Strange dreams
- Impaired kidney function
- Asthma symptoms
- Inflammation of the liver